ORCID Research Profile
Yaroslau Compta Hirnyj
Position: Adjunct medical lecturer
ycompta (at) ub.edu
Contact details
Dr. Compta Hirnyj, Yaroslau
Department of Medicine
Faculty of Medicine, Casanova 143
08036 Barcelona (Spain)
ycompta (at) ub.edu
They has characterized the non motor symptoms of LRRK2- Parkinson disease and created a repository of biological material of subjects with LRRK2 associated Parkinson disease and their asymptomatic relatives.
In a large post-mortem study they documented multiorgan involvement with alpha synuclein aggregates in Parkinson disease and described for the first time alpha-synuclein aggregates in epicardial fat tissue in living subjects without parkinsonism. a probable preclinical marker of Parkinson disease They characterized the non motor symptoms of Parkinson disease in a cohort of 100 cases and defined premotor symptoms predictors of parkinsonism.
They consolidated a line of research on cerebrospinal fluid biomarkers in Parkinson dementia and established a correlation between neurochemical Alzheimer and imaging markers in Parkinson disease. Work has been initiated in Parkinson and atypical parkinsonism patients to characterize in vivo brain amyloid and tau pathology with PET technology.
Research Interest
Development of research projects which yield results that hopefully have short term application, with a view to improving the diagnosis and treatment of neurodegenerative diseases.
Current Research Line
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LRRK2 associated Parkinson disease. Clinical, imaging and genetic characterizarion of the prodromic phase.
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Neurochemichal, genetic and imaging biomarkers of cognitive deterioration in Parkinson disease.
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Generation of IPSC-derived dopaminergic neurons by reprogramming of idiopathic and genetic Parkinson’s disease patient skin fibroblasts. Molecular characterization and elucidation of underlying pathophysiologic mechanisms.
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Study of the biological and molecular bases of Parkinson’s disease in preclinical stages: mild cognitive impairment and pre-motor Parkinson’s disease.
Technologies/Methods
- Disease / disorder characterization: Endophenotypification studies
- Assessment of new treatments: Clinical trials, non-dopa agents
- Methods for diagnostic: Cerebrospinal fluid (CSF) and imaging biomarkers
- Clinical data: Collaborative clinical registries
- Development of new tools / technologies / computational methods: Implement new CSF and PET markers
Highlighted Publications
Baggio HC, Segura B, Sala-Llonch R, Marti MJ, Valldeoriola F, Compta Y, Tolosa E, Junqué C. Cognitive impairment and resting-state network connectivity in Parkinson’s disease. Hum Brain Mapp. 2015 Jan;36(1):199-212.
Baggio HC, Segura B, Garrido-Millan JL, Marti MJ, Compta Y, Valldeoriola F, Tolosa E, Junque C. Resting-state frontostriatal functional connectivity in Parkinson’s disease-related apathy. Mov Disord. 2015 Apr 15;30(5):671-9.
Pont-Sunyer C, Hotter A, Gaig C, Seppi K, Compta Y, Katzenschlager R, Mas N, Hofeneder D, Brücke T, Bayés A, Wenzel K, Infante J, Zach H, Pirker W, Posada IJ, Álvarez R, Ispierto L, De Fàbregues O, Callén A, Palasí A, Aguilar M, Martí MJ, Valldeoriola F, Salamero M, Poewe W, Tolosa E. The onset of nonmotor symptoms in Parkinson’s disease (the ONSET PD study). Mov Disord. 2015 Feb;30(2):229-37.
Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Compta Y, Revesz T, Lees A, Cairns NJ, Halliday GM, Mann D, Pickering-Brown S, Powell J, Lunnon K, Lupton MK; International Parkinson’s Disease Genomics Consortium (IPDGC), Dickson D, Hardy J, Singleton A, Bras J. Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson’s and Alzheimer’s diseases. Neurobiol Aging. 2016 Feb;38:214.e7-214.e10.
Vilas D, Ispierto L, Álvarez R, Pont-Sunyer C, Martí MJ, Valldeoriola F, Compta Y, de Fabregues O, Hernández-Vara J, Puente V, Calopa M, Jaumà S, Campdelacreu J, Aguilar M, Quílez P, Casquero P, Lomeña F, Ríos J, Tolosa E. Clinical and imaging markers in premotor LRRK2 G2019S mutation carriers. Parkinsonism Relat Disord. 2015 Oct;21(10):1170-6.
Urbizu A, Canet-Pons J, Munoz-Marmol AM, Aldecoa I, Lopez MT, Compta Y, Alvarez R, Ispierto L, Tolosa E, Ariza A, Beyer K. Cystatin C is differentially involved in multiple system atrophy phenotypes. Neuropathol Appl Neurobiol. 2015 Jun;41(4):507-19.