Research line
Huntington´s disease: toward an understanding of pathological mechanisms involved in cognitive and psychiatric symptoms.
Identification of new pharmacological targets to ameliorate or prevent the most important clinical hallmarks in HD: Motor, cognitive and emotional disturbances.
Capacities
- Disease / disorder characterization: Behaviour (motor, cognition, emotional)
- Assessment of new treatments: In vivo and in vitro analysis of cell death, biochemical parameters, synaptic function, behaviour
- In vitro models: Neuronal striatal cell lines
- In vivo models: Huntington´s disease mouse models
Keywords: synaptic plasticity deficits, neuroprotection, long-term memory impairments, depression, p75/TrkB/BDNF, Cdk5.
Contact
Dr. Sílvia Ginés Padrós
silviagines (at) ub.edu
