Research line
Glutamatergic receptors in synaptic transmission.
- Characterization and identification of interacting proteins regulating AMPA receptor function.
- Studies of synaptic plasticity (long term potentiation and depression).
- Characterization of newly synthesized therapeutic compounds on NMDA receptors.
- Functional studies on glutamate receptor mutations related to intellectual disabilities.
Capacities
- Disease / disorder characterization: Electrophysiological characterization of glutamate ion channels dysfunction
- Assessment of new treatments: Ion channel blockers and positive allosteric modulators
- In vitro models: Cell lines, neuronal cultures, hippocampal slices
- Others: Electrophysiology in several recording configurations
Keywords: electrophysiology (patch-clamp), ionotropic glutamate receptors, hippocampal pyramidal neurons, long term plasticity, single channel conductance, auxiliary subunits.
Contact
Dr. David Soto del Cerro
davidsoto (at) ub.edu
